Donald trump, after The Lancet published a scientific article where it categorically maintains that after various studies it could be verified that the hydroxychloroquine increases the risk of death for patients hospitalized by COVID-19. “data-reactid =” 12 “> A categorical official denial received this Friday, May 22, the President of the United States, Donald Trump, after The Lancet published a scientific article where he categorically maintains that after various studies it was found that hydroxychloroquine increases the risk of death for patients hospitalized for COVID-19.

In the study I know examined more than 96,000 people hospitalized with coronavirus, those treated with hydroxychloroquine or related chloroquine had a higher risk of death than patients who did not receive the medications.“data-reactid =” 13 “> The study examined more than 96,000 people hospitalized with coronavirus, those treated with hydroxychloroquine or related chloroquine had a higher risk of death than patients who did not receive the medications.

On the other hand, the research suggests important discussions:

Chloroquine and hydroxychloroquine are associated with cardiovascular toxicity problems, particularly due to their known relationship with electrical instability, characterized by QT interval prolongation (the time required for ventricular depolarization and repolarization). This mechanism is related to blocking the hERG potassium channel, which lengthens ventricular repolarization and the duration of ventricular action potentials. This can trigger ventricular arrhythmias. These arrhythmias occur with high frequency during COVID-19 disease. In addition, people with cardiovascular disease represent a vulnerable population that experiences worse results with COVID-19. Use of chloroquine or hydroxychloroquine in combination with a macrolide (Azithromycin and Clarithromycin) is designed to use its antimicrobial properties synergistically. Macrolides are antibiotics with immunomodulatory and anti-inflammatory effects. However, these drugs increase the risk of sudden cardiac death.

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